What doctors wish patients knew about the BA.2 Omicron subvariant

With the rolling back of mask requirements and physical distancing, many people have been on a search for a new normal. But there is still reason to be cautious. The highly transmissible and contagious BA.2 Omicron subvariant—dubbed “stealth” Omicron—is now the dominant strain in the United States, causing more than 85% of all COVID-19 cases, according to the Centers for Disease Control and Prevention (CDC). This has led to more questions.

Based on the CDC’s genomic surveillance, the BA.2 or stealth Omicron subvariant is responsible for most new SARS-CoV-2 infections in the U.S. BA.2 is a subvariant of the original SARS-CoV-2 Omicron variant (B.1.1.529), along with BA.1.1 and BA.3.

The BA.2 subvariant has been referred to as stealth Omicron because it contains genetic mutations that can make it harder to distinguish from the Delta variant using PCR tests compared to the original Omicron variant. That means that while the test can detect a BA.2 infection, it looks like it is the Delta variant instead.

The AMA’s What Doctors Wish Patients Knew™ series provides physicians with a platform to share what they want patients to understand about today’s health care headlines, especially throughout the COVID-19 pandemic.

In this installment, AMA member Nancy Crum, MD, an infectious disease specialist at Avita Health System in Galion, Ohio, discusses what patients need to know about the BA.2 Omicron subvariant. Dr. Crum is also an alternate delegate in the AMA House of Delegates for the Infectious Diseases Society of America.

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