Mutations

A new COVID-19 challenge: Mutations rise along with cases The race against the virus that causes COVID-19 has taken a new turn: Mutations are rapidly popping up, and the longer it takes to vaccinate people, the more likely it is that a variant that can... AP NEWS

The race against the virus that causes COVID-19 has taken a new turn: Mutations are rapidly popping up, and the longer it takes to vaccinate people, the more likely it is that a variant that can elude current tests, treatments and vaccines could emerge.

NATURE

A mutation undercuts the immune response to the COVID virus 

A handful of mutations to SARS-CoV-2 can help it to escape the immune response mounted by a subset of infected people.

Researchers have identified thousands of mutations in SARS-CoV-2 samples, but the vast majority are unlikely to have much effect on the virus’s biology. To identify potentially important mutations, Jesse Bloom at the Fred Hutchinson Cancer Research Center in Seattle, Washington, and his colleagues studied antibodies against SARS-CoV-2 isolated from the blood serum of people who had recovered from COVID-19 (A. J. Greaney et al. Preprint at bioRxiv https://doi.org/ghr85d; 2021).

The team tested the antibodies’ response to samples of the virus’s spike protein. Each sample protein carried different versions of a region called the receptor binding domain (RBD), which recognizes host cells and is a major target for antibodies.

https://www.nytimes.com/live/2021/01/08/world/covid-19-coronavirus#false-reports-of-a-new-us-variant-originated-from-dr-deborah-birx-on-the-task-force

Reports of a highly contagious new variant in the United States, published on Friday by multiple news outlets, are based on speculative statements made by Dr. Deborah Birx and are inaccurate, according to several government officials.

The erroneous report originated at a recent meeting where Dr. Birx, a member of the White House coronavirus task force, presented graphs of the escalating cases in the country. She suggested to other members of the task force that a new, more transmissible variant originating in the U.S. might explain the surge, as another variant did in Britain.