Oral antiviral simnotrelvir shows promise for treating mild COVID-19 The length of COVID-19 symptoms was on average 36 hours shorter in the simnotrelvir group. CIDRAP

..in the New England Journal of Medicine Chinese researchers have published positive trial results of simnotrelvir, an oral antiviral that can shorten the duration of mild to moderate COVID-19 symptoms.

Unlike with Paxlovid or other antivirals tested against the virus, the simnotrelvir trial was conducted on mostly healthy young adults, none of whom had severe symptoms. The study included 1,208 patients enrolled at 35 sites in China; 603 were assigned to receive simnotrelvir, and 605 to receive placebo. The study ran from August to December 2022.

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