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Opinion: Project NextGen is ignoring new COVID-19 antivirals when we need them most

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Opinion: Project NextGen is ignoring new COVID-19 antivirals when we need them most

As this recent holiday surge reminds us, new dominant variants like HV.1, EG.5, and BA.2.86 are thriving despite our existing vaccines and treatments. COVID-19 remains a pressing threat, particularly for those most vulnerable to severe disease.

Yet, the $5 billion initiative being administered by Biomedical Advanced Research and Development Authority (BARDA)-led Project NextGen has failed to invest in the next generation of oral COVID-19 antivirals. Next-generation oral antivirals, some of which are already in development, are likely to be the most practical and productive investment to help protect our most at-risk individuals and bring us closer to moving beyond this pandemic. However, without government/private partnerships similar to what were implemented for vaccines and monoclonal antibody development, new next-generation oral antivirals currently in development may not reach the finish line.  

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